Dor spleen transplantation in miniature swine studied in transplantation Biology Research Center at Massachusetts General Hospital / Harvard Medical School in Boston, led by Professor David KC Cooper and Professor David H Sachs Spleen transplant received a short course of immunosuppressive therapy, after the transplanted spleen was adopted. The receiver is in the direction of the donor response in vitro, so that a kidney from the same donor can be mechanisms leading to immunosuppression. One of the possible mechanisms leading to though though spleen transplantation, the fact that. The donor hematopoietic stem cells in the spleen engraft recipients lymphoid organs, including the bone marrow, so consider teaching the immune system to the donor as self .
However, rejection of transplanted organs more difficult long-term survival. The ultimate goal in clinical transplantation of donor – specific immunological tolerance to achieve against the transplanted organ. If tolerance can be achieved, it will be possible to offer an organ transplant patients, which works in the long term, without the complications of immunosuppressive therapy, including cardiovascular disease, opportunistic infections and malignancies.. Significant progress has achieved in the field of transplantation and immunosuppressive therapy in the last 50 years.Vactual GE, Outcomes from patients who participate in randomized controlled studies comparison with similar patients attempted similar surgeries who do not take. The Cochrane Database of Systematic Reviews 2007, Issue 2.
Hopewell south, Graue Literatur into meta-analyzes randomized trials of health care interventions. Which Cochrane Database of Systematic Reviews 2007, Issue 2.